2-Chloronicotinic acid (2942-59-8)

2-Chloronicotinic acid (2942-59-8)

Use Industrial mass production

Alias 2-chloro-3-pyridinecarboxylic acid; 2-chloropyridine-3-carboxylic acid; 2-chloronicotinic acid; 2-chloronicotinic acid; 2-chloro-3-pyridinecarboxylic acid; 2-chloronicotinic acid; 2-Chloronicotinic acid, 99%; 2-chloro-3-carboxypyridine

Purity 99%

Specification 25kg/drum

Molecular formula 2-Chloronicotinic acid

Product English name 2-Chloronicotinic acid

CAS: 2942-59-8

Chinese alias: 2-chloro-3-pyridinecarboxylic acid; 2-chloropyridine-3-carboxylic acid; 2-chloronicotinic acid; 2-chloronicotinic acid; 2-chloro-3-pyridinecarboxylic acid; 2-chloronicotine acid; 2-chloronicotinic acid, 99%; 2-chloro-3-carboxylic acid pyridine

English name: 2-Chloronicotinic acid

Properties: Melting point; 176-178°C (dec.)(lit.) Storage conditions; Store below +30°C. Form Powder Color White to cream BRN; 119023 InChIKey IBRSSZOHCGUTHI-UHFFFAOYSA-N CAS Database 2942-59-8(CAS DataBase Reference) EPA Chemical Substance Information 3-Pyridinecarboxylic acid, 2-chloro-(2942-59-8)

Uses: chemical properties; this product is a colorless solid, m.p.>175℃ (decomposition), insoluble in water, soluble in benzene, toluene and other organic solvents. purposes; 2-chloro-3-pyridine carboxylic acid is the intermediate of herbicides nicosulfuron, diflufenac. purposes; pharmaceutical and pesticide intermediates. Uses; used as pharmaceutical intermediates for the manufacture of nicotinic acid, nicotinic acid, etc.; pesticide intermediates for the manufacture of nicosulfuron, diflufenacil, etc.; 2-chloro-3-pyridinecarboxylic acid is Intermediates of herbicides nicosulfuron and diflufenac. ; Pharmaceutical and pesticide intermediates. Production method; its preparation method has the following two.

(1) Using 3-methylpyridine as raw material, first react with hydrogen peroxide* to generate N-oxy-3-methylpyridine, then in the presence of acid binding agent diiso*propylamine, add dropwise in solvent Phosphorus oxychloride is the chlorinating agent to carry out cyclic chlorination to obtain a mixture of 2-chloro-5-methylpyridine and 2-chloro-3-methylpyridine. The separation technique combining crystallization and rectification can be obtained respectively. 2-Chloro-5-methylpyridine and 2-chloro-3-methylpyridine. 2-Chloro-3-methylpyridine is subjected to side chain chlorination to obtain 2-chloro-3-trichloromethylpyridine, which can be further hydrolyzed to obtain 2-chloro-3-pyridinecarbonyl chloride or 2-chloro-3-pyridinecarboxylic acid (2-chloronicotinic acid). (2) Introduce chlorine gas into the mixed solution of phosphorus oxychloride and phosphorus trichloride, control the temperature at about 60°C, until the remaining chlorine gas escapes, cool and add nicotinic acid N-oxide in batches, heat and mix liquid in. The reaction is carried out at 100～105℃ for 1～1.5h, and the reaction mixture is stirred for 30min after the reaction mixture becomes transparent, and the phosphorus oxychloride is removed under reduced pressure. The obtained residue is cooled to room temperature, and water is added to obtain the finished product.